3-Dimensional Structure determination of nucleic acids and protein-nucleic acid complexes (Figure 6) provides insight into how diseases initiate, manipulate and evolve at the molecular level.Understanding molecular structure 3-dimensionally facilitates new drug discovery, and ultimately better patient care.X-ray crystallography is the most powerful and most accepted tool for 3-dimensional structure determination at atomic level.Incorporating selenium into RNA or DNA allows several advantages over conventional methods:
ØFacilitates phase determination
ØPotentially facilitates crystallization of nucleic acids and protein-nucleic acid complexes
ØResults in higher quality crystals
ØGreater molecular stability under X-ray crystallography studies, especially during radiation and diffraction data collection
Ø Innovative Technologies have been established for discovering Novel Drugsto target nucleic acids and protein-nucleic acid complexes.