SeNA Researchhas been established to develop and market products and services on the basis of our innovative and patented technologies. These technologies include the alteration of nucleic acids by replacing oxygen with selenium. We offer cutting-edge technologies to study X-ray crystal structures and functions of nucleic acids and their protein complexes.
Determining three-dimensional structures of nucleic acid molecules and their protein complexes is invaluable for understanding biological systems at the molecular level.Three-dimensional understanding is important because it dramatically facilitates new drug development and more efficient patient care.X-ray crystallography is the most powerful tool for three-dimensional structure determination.Through years of research, the management team has successfully developed a novel technique to take advantage of the power of X-ray crystallography.These new technologies involve derivatization strategies that replace oxygen with selenium in nucleic acids.Replacing oxygen with selenium has several advantages over conventional methods of using bromine or iodine.One such advantage is that selenium can be selectively introduced to a variety of positions via oxygen replacement, rather than single-position capability for bromine and iodine.Proper positioning can avoid disruption of structure and function caused by the modification (Fig. 2).
Fig. 2. Electron density maps and structures of the selenium-derivatized DNA duplexes. Red balls represent selenium. Se-DNA Crystal Structure with 1.28 Å Resolution