Novel technologies for X-ray crystal structure and function studies of nucleic acids and protein-nucleic acid complexes have been discovered and developed by SeNA Research, Inc. These exciting, convenient, and time-and-effort-saving methodologies using selenium-derivatized nucleic acids (SeNA), which faciliate crystal growth and quality, will allow phase and structure determination with high resolution (Figure 1-2).Selenium derivatization of nucleic acids has been proven superior to conventional methods as evidenced by:
• More efficient phase determination • Faster crystal growth with broader crystallization conditions • Higher diffraction-quality crystals • Greater molecular stability during X-ray radiation and diffraction data collection
• Fine tool for mass spectrometry research with selenium isotopes
The Innovative Technologies have been established for discovering Novel Drugs targeting nucleic acids (such as RNA) and protein-nucleic acid complexes.
Figure 1. 2'-Se-Thymidine Nucleotide in dsDNA Structure